Covid-19 Infected Don't Need Second Shot: ICMR
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A single dose of the Covishield vaccine has been found sufficient to protect Covid-infected people who have attained immunity after recovering from the infection, revealed a study by researchers at the ICMR. The team members said relieving many recovered patients from the second dose will significantly help in managing the vaccine shortage in India.

People between 18 and 75 years of age, covering both males and females, were studied by the experts. The results showed that among the seropositive cases, the second dose of vaccine did not raise the antibody titre any higher compared to the first dose. “Interestingly, it was observed that the IgG antibody titre was considerably higher in previously seropositive participants who received only one dose of vaccine compared to the seronegative group who received both doses of vaccine,” stated the study report.

The study suggested that a single dosage of the vaccine may be enough to produce an efficient immune response in previously infected patients, even to those with moderate illness. During the study, the IgG antibodies, which determine the immunity level of an individual, were estimated at three different time intervals, pre-vaccination, 25-35 days post first dose vaccination and again 25-35 days post-second shot.

Notably, they found the IgG antibody titre was significantly high among people who tested positive earlier and got the single dose of vaccine. A total of 121 participants were included to study the immune response to Covishield in previously infected or uninfected people.

“A single dose of Covishield vaccine might be sufficient to induce an effective immune response in subjects with prior SARS-CoV2 infection. Stratifying vaccines based on their (a beneficiary's) SARS-CoV2 IgG antibody titre before vaccination would help in meeting the increasing vaccine demand and could be effective to circumvent further waves of the pandemic in India,” read the study.

Source:
https://www.medrxiv.org/content/10.1101/2021.06.15.21258346v1
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