Covid Antibodies May Last From Days To Years, Depending On I
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Antibodies against the novel coronavirus wane at different rates, according to a new study. The severity of Covid-19 severity could be a deciding factor in having longer-lasting protection against reinfection. Recovered patients with low levels of neutralising antibodies may still be protected from reinfection if they have robust immunity in the form of the body's T cells.

In the study, scientists, followed 164 Covid-19 patients for six to nine months, analysing their blood for neutralising antibodies against the SARS-CoV-2 virus, their T cells and immune system signalling molecules. They then used this information to train a machine learning algorithm to predict the trajectories of people's neutralising antibodies over time.

Based on the analysis, the researchers categorised people into five groups depending on how long their antibodies lasted. The first group, included those who never developed detectable neutralising antibodies -- also called the 'negative' group -- and comprised 11.6 per cent of the patients in the study.

The 'rapid waning' group, which included 26.8 percent of the patients, had varying early levels of antibodies that waned quickly, the scientists said. According to the researchers, the 'slow waning' group, which included 29 percent of the participants, tested mostly positive for antibodies at six months.

The 'persistent' group, comprising 31.7 percent of the individuals, showed little change in their antibody levels up to 180 days and, they said, adding that the 'delayed response' group showed a significant rise in neutralising antibodies during late convalescence. According to the study, patients, including those from the 'negative group', displayed sustained T-cell immunity six months after initial infection.

Based on the results, the scientists emphasised the importance of public health and social measures in ongoing pandemic outbreak response. They said the presence of T-cell immunity provides hope of longer-term protection, adding that more studies are needed to confirm the findings.

Source:
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(21)00025-2/fulltext
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