Cryptococcal fungemia and probable histoplasmosis in an HIV+
Histoplasmosis and cryptococcosis are major causes of morbimortality in immunocompromised patients due to HIV infection. The present case has been reported in the journal BMC Infectious Diseases.

The authors report a case of a patient with HIV infection with a CD4 T lymphocyte cell (CD4) count of 2 cells/mm3, who presented with 6 months of diarrhea, non-productive dry cough, nocturnal diaphoresis, fever, weight loss, and a maculopapular rash.

He had a concurrent infection with three opportunistic microorganisms: fungemia by cryptococcosis, disseminated histoplasmosis confirmed by detection of the antigen in urine and chronic diarrhea by cryptosporidiosis confirmed by direct observation in feces by modified Ziehl-Neelsen stain. The patient received antifungal treatment with a satisfactory outcome.

Case highlights:-
-In the case presented, the diagnosis of two opportunistic infections (Cryptosporidiosis and Cryptococcosis) was confirmed and the probable diagnosis of histoplasmosis was considered based on the results of the urinary antigen for histoplasmosis and clinical plausibility, mainly for cutaneous manifestations and the random micronodular compromise seen in chest images.

- In this patient the bronchoalveolar fluid studies were negative and unfortunately no biopsies were taken.

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