Cutaneous Complications After BCG Vaccine
Bacille Calmette-Guerin (BCG) vaccine may cause some cutaneous complications at the injection site. Although some of these are normal reactions, unexpected complications may be seen. Clinical features, treatment modalities and outcomes of these complications have not been clearly defined in literature. The present study, published in the International Journal of Clinical Pediatrics aimed to determine the local cutaneous complications after BCG vaccine and clinical experiences.

Twenty patients were diagnosed as having local cutaneous complications. Abscess formation (30%), localized inflammation signs (45%), purulent discharge (10%), crust (10%) and eczematous lesion (5%) were found as local cutaneous complications. Drainage was performed in 70% patients.

Oral amoxicillin clavunate therapy was given to four patients due to isolating Staphylococcus aureus, Staphylococcus hominis, and Exiguobacterium aurantiacum from the drainage or purulent discharge culture. Anti-tuberculosis drugs (isoniazid and rifampicin) were used in six (30%) patients.

Five of them had positive acid-resistant bacilli, tuberculosis polymerase chain reaction or tuberculosis culture results and one patient was diagnosed as having a lupus vulgaris because histopathological examination of his lesion revealed granulomatous dermatitis. In addition, there was no lesion to drain in four patients and they were followed without treatment. On follow-up, all lesions completely recovered.

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