Cystadenoma of the tongue: report of a case with long-term f
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Cystadenoma is a rare benign salivary gland neoplasm characterized by a predominantly multicystic growth pattern. It accounts for 4% of all salivary gland neoplasms. A 63-year-old man was referred to hospital for treatment of a nodule on his tongue. His medical history included Wolff–Parkinson–White syndrome and atrial fibrillation, both of which were controlled adequately by his primary care physician. Physical examination revealed very slight swelling at the right edge of his tongue. The patient reported some spontaneous pain. It was diagnosed as inflammation of the foliate papilla; the patient was followed-up with a gargle prescription. In September 2005, an elastic soft mass, 4 mm in diameter, was observed along the right edge of his tongue.

It was clinically diagnosed as a benign tumor and removed under local anaesthesia. Microscopically, the lesion was composed of multiple cysts of various sizes and shapes, with or without papillary intraluminal short projections. Many cyst cavities contained eosinophilic fluid. The lesion was well-delineated, but the capsular structure was ill-defined. The stroma was fibrous connective tissue without lymphocytic components. The cystic cavities were lined by a bilayered epithelium composed of luminal columnar cells and basal cuboidal cells. Both luminal and basal epithelial cells were eosinophilic; some clear cells were seen. Mitotic figures and cellular atypia of epithelial cells were not seen. Immunohistochemically, both luminal and basal cells were CAM5.2+, basal cells were p63+, apical half of the luminal cells were 34?E12+, and the liminal surface was CEA+. The specimen was diagnosed as cystadenoma, based on the histopathological findings.