DASH diet reduces serum urate, especially in those with hype
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
The Dietary Approaches to Stop Hypertension — or DASH — diet successfully reduces serum urate, particularly among those with hyperuricemia, according to data published in Arthritis & Rheumatology.

This study aimed to determine whether the Dietary Approaches to Stop Hypertension (DASH) diet or an alternative, simplified diet, emphasizing high fiber fruit and vegetables, lowers serum urate (SU).

Researchers conducted a secondary study of the DASH feeding study, a 3-arm, parallel-design, randomized trial of 459 adults with systolic blood pressure (SBP) <160 mmHg and diastolic blood pressure (DBP) of 80-95 mmHg, not on BP medications.

Participants were randomized to 8 weeks of monitored feeding and ate one of three diets: 1) a typical American diet (control), 2) a fruit and vegetable (FV)-rich diet but otherwise similar to control, or 3) the DASH diet which was rich in fruit, vegetables, and low-fat dairy products, and reduced in fat, saturated fat and cholesterol. Body weight was kept constant throughout the study. SU was measured at baseline and after 8-weeks of feeding.

-- Of the 327 participants with available specimens (mean age 45.4±11.0 years, 47% women, 50% black), mean baseline SU was 5.7±1.5 mg/dL.

-- Compared to the control diet, the FV diet reduced SU by 0.17 mg/dL and DASH reduced SU by 0.25 mg/dL.

-- These effects increased with increasing baseline SU levels with DASH, but not with FV.

Conclusively, the DASH diet reduced SU, particularly among those with hyperuricemia. These findings support the growing need for a dedicated trial to test DASH among patients with hyperuricemia and gout.

Source: https://onlinelibrary.wiley.com/doi/10.1002/art.41614