DNA methylation in gestational diabetes and its predictive v
In this study, forty-eight randomly selected pregnant women formed the discovery cohort (24 with GDM and 24 controls) and 252 pregnant women (94 with GDM and 158 controls) formed the replication cohort. GDM women were re-evaluated 4 years postpartum. Researchers identified three CpG sites related to LINC00917, TRAPPC9 and LEF1 that were differentially methylated in women with GDM and abnormal glucose tolerance, and the sites associated with LINC00917 and TRAPPC9 were independently associated with an abnormal glucose tolerance status four-years postpartum after controlling for clinical variables. Moreover, the site associated with LINC00917 and the combination of the three sites had the highest predictive values. These results suggest that some of these sites may be implicated in the development of GDM and postpartum abnormal glucose tolerance.

Source: https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac462/6653115?rss=1&login=false