Decreased Serum 25(OH)Vit-D levels linked with risk of Pedia
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The association between the risk of fractures and suboptimal vitamin D status remains controversial in children. This meta-analysis suggested that serum 25(OH)Vit-D levels were lower in pediatric cases with fractures. 25-hydroxyvitamin D (25(OH)Vit-D) levels less than 50 nmol/L were associated with increased fracture risk in children.

This study aimed to assess the association between serum 25(OH)Vit-D and the risk of fractures in children, and to explore the sources of heterogeneity and investigate their impact on results.

Systematic review and meta-analysis were conducted for observational studies comparing serum 25(OH)Vit-D levels between fracture and non-fracture pediatric cases. The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS).

Results:
--Analysis on 17 case-control and 6 cross-sectional studies (2929 fracture cases and 5000 controls) suggested that 25(OH)Vit-D was lower in fracture cases than in controls (pooled mean difference (MD) = - 3.51 nmol/L) with a heterogeneity (I2) of 73.9%.

--The sensitivity analysis which merged the case-control studies that had a NOS score more than 4 showed a pooled MD of - 4.35 nmol/L with a heterogeneity (I2) of 35.9%.

--Pooled odds ratio of fracture in subjects with 25(OH)Vit-D less than 50 nmol/L compared to subjects with 25(OH)Vit-D more than 50 nmol/L was 1.29 (I2 less than 1%).

This study concluded that serum 25(OH)Vit-D levels were lower in pediatric fracture patients. In girls, 25(OH)Vit-D levels less than 50 nmol/L were linked to an increased risk of fracture.

Source: https://link.springer.com/article/10.1007/s00198-020-05814-1
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