Dengue and Zika virus family uses an unexpected approach to
A group of researchers in Germany have discovered that flaviviruses - a family that includes Dengue, Zika and West Nile viruses - use an unexpected mechanism to hijack the cell's machinery to replicate themselves compared to many other RNA viruses. The findings, published in mBio®, an open-access journal of the American Society for Microbiology, highlight new ways by which viruses manipulate human cells and may reveal new targets for designing antiviral therapies.

Dengue virus and Zika virus are both positive-strand RNA flaviviruses, which means that once a virus particle infects a cell, its RNA genome can be immediately translated by cellular machinery into viral proteins to make new virus particles and spread the infection. Dengue virus can cause febrile illness, hemorrhagic fever, and even death, and infects an estimated 390 million people worldwide each year. Zika virus can also cause fevers and has been linked to severe neurological birth defects in newborns born to infected mothers....