Desmopressin effects on bleeding during functional endoscopi
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The study shows that Desmopressin (DDAVP) can reduce the bleeding during functional endoscopic sinus surgery on patients with chronic rhinosinusitis and provides better vision.

In this study researchers aimed to determine whether Desmopressin (DDAVP) can alter bleeding and improves surgeon visual field and decrease operation time or lessen the use of anesthesiology medication in a clinical trial study.

This study is a randomized clinical trial using the permuted block randomization method. 44 patients were enrolled in the study and divided into two equal intervention-control groups. The intervention group received a maximum dose of 0/2 micrograms per kg of DDAVP. In the control group, 30 min before the surgery, 100 ml of normal saline will be injected.

The amount of bleeding was 517/17 cc in the control group during surgery while it was 387/72 cc in the group receiving DDAVP which is significantly lower. The satisfaction of surgeons regarding suitable visual field was 6/45 in the control group while it was 3/77 in DDAVP receivers which are lower.

It seems that intravenous DDAVP can reduce bleeding during surgery and offer an enhanced vision for surgeons during surgery but it has no potential efficacy on reduction of the period of surgery and need for anesthesiology medication like remifentanil and isoflurane.

American Journal of Otolaryngology
Source: https://doi.org/10.1016/j.amjoto.2021.103024
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