Despite the potential increased risks of COVID-19 for pregna
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Despite the potential increased risks of COVID-19 for pregnant patients and their newborns, there remain significant gaps in knowledge on the clinical course of disease and the overall prognosis in this population. To date, studies of SARS-CoV-2 infection in pregnancy have primarily focused on hospitalized patients. Currently, there are limited data on longitudinal changes in symptoms over time and total duration of disease among the pregnant outpatient population, which includes the majority of patients with COVID-19. Data on clinical evolution are critical to guide and inform counseling and risk stratification for pregnant patients with COVID-19. A study was conducted to describe the clinical presentation, symptomology, and disease course of coronavirus disease 2019 (COVID-19) in pregnancy.

The PRIORITY (Pregnancy CoRonavIrus Outcomes Registry) study is an ongoing nationwide prospective cohort study of people in the United States who are pregnant or up to 6 weeks post-pregnancy with known or suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We analyzed the clinical presentation and disease course of COVID-19 in participants who tested positive for SARS-CoV-2 infection and reported symptoms at the time of testing.

Of 991 participants enrolled from March 22, 2020, until July 10, 2020, 736 had symptoms of COVID-19 at the time of testing; 594 tested positive for SARS-CoV-2 infection and 142 tested negative in this symptomatic group. The mean age was 31.3 years, and 37% will nulliparous. Ninety-five percent were outpatients. Thirty-one percent of study participants were Latina, and 9% were Black. The average gestational age at enrollment was 24.1 weeks, and 13% of participants were enrolled after pregnancy. The most prevalent first symptoms in the cohort of patients who tested positive for SARS-CoV-2 infection were cough (20%), sore throat (16%), body aches (12%), and fever (12%). The median time to symptom resolution was 37 days. One quarter (25%) of participants who tested positive for SARS-CoV-2 infection had persistent symptoms 8 or more weeks after symptom onset.

COVID-19 has a prolonged and nonspecific disease course during pregnancy and in the 6 weeks after pregnancy.

Source:https://journals.lww.com/greenjournal/Fulltext/2020/12000/Clinical_Presentation_of_Coronavirus_Disease_2019.10.aspx
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