Devic’s syndrome in aquaporin-4 antibody negative patient. W
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Neuromyelitis optica also known as Devic’s disease is a rare immune mediated demyelinating condition of the central nervous system affecting predominantly the optic nerves and the spinal cord. NMO can be seen as a part of another immune-mediated syndrome, such as lupus, multiple sclerosis, but often no underlying cause can be found. It should be included as one of the central nervous system (CNS) neuroinflammatory disorders. Currently, NMO is considered as a central nervous system AQP4 channelopathy which causes variable damage predominantly to the optic nerves and spinal cord, although other CNS structures that highly express AQP4 may be also affected. The authors describe an extremely rare case of neuromyelitis optica and the aim of this paper is to call attention for the cases of NMO whith NMO-IgG negative.

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