Dexamethasone Trial Results Confirm COVID-19 Benefits But Al
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The keenly-awaited full results from a U.K.-based RECOVERY trial of the steroid dexamethasone were published Friday, confirming its life-saving benefits for COVID-19 patients on ventilators but suggesting it may cause harm if given too early.

A total of 2,104 hospitalized patients were assigned to receive six milligram daily doses of the medicine for up to 10 days, and 4,321 to receive usual care, with the rate of deaths compared after 28 days.

Among patients on ventilators, the rate of death for patients on the drug was 29.3 percent compared to 41.4 percent on those without. In other words, this group saw a 29 percent reduction in mortality.

In patients who were given oxygen but through less invasive means, the benefit was smaller -- 23.3 percent on dexamethasone died versus 26.2 who were not on it.

However, there was no benefit among the group who weren't receiving any oxygenation at the time the trial started. In this cohort, 17.4 percent on the steroid died compared to 14 percent who did not receive it -- suggesting the drug increased their mortality risk.

This is because the drug works by suppressing the abnormal immune response that damages the body's organs, rather than attacking the virus.

"This is perfectly compatible with knowing that early on in infection, you need the immune system to suppress the virus." researchers said.

The authors of the paper, which appeared in the New England Journal of Medicine, added that getting benefit from the drug "is dependent on a selection of the right dose, at the right time, in the right patient."

Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2021436?query=featured_home
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Dr. s●●●●●r v●●a
Dr. s●●●●●r v●●a Paediatrics
Very informative
Jul 18, 2020Like
Dr. R●●●●●●●●r G●●●●i
Dr. R●●●●●●●●r G●●●●i pediatrics
Good information
Jul 18, 2020Like