Dexamethasone versus placebo for prevention of nausea, vomit
Post-operative nausea and vomiting (PONV) is a disturbing issue. Dexamethasone has been suggested for the prevention of PONV.

The aim of the present study was to evaluate the efficacy of dexamethasone as an anti-emetic and analgesic following total abdominal hysterectomy.

The study was performed as a double-blind, placebo-controlled randomized clinical trial on 102 women undergoing an open total abdominal hysterectomy. The intervention group received 8 mg dexamethasone 1 h before surgery, and the control group received a placebo.

- The total number of emesis episodes during the 24 h after surgery did not show a significant difference between the two groups, however, the number of emesis episodes in hours 2 and 4 after the surgery were less in the intervention group, but not in hours 0, 6, 12 and 24.

- The nausea severity in hours 0, 2, 4, 6, and 12 after the surgery, was less in the intervention group. The severity of pain was not different between the two groups.

In conclusion, dexamethasone can be considered as an effective prophylaxis for PONV for the first 24 h after an open total abdominal hysterectomy, but it has limited effects on the management of early onset of PONV; between 0 and 2 h after surgery.

Journal of Obstetrics and Gynaecology