Diabetes is a risk factor for the progression and prognosis
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
To figure out whether diabetes is a risk factor to influence the progression and prognosis of COVID‐19, 174 COVID‐19 patients who were admitted to Wuhan Union Hospital from 10 February 2020 to 29 February 2020 were included in this study according to the inclusion criteria. Their basic information, laboratory examinations, chest computed tomography (CT) scans as well the treatment measures were collected and analysed.

It was found that COVID‐19 patients without other comorbidities but with diabetes (n = 24) were at higher risk of severe pneumonia, release of tissue injury‐related enzymes, excessive uncontrolled inflammation responses and hypercoagulable state associated with dysregulation of glucose metabolism. Furthermore, serum levels of inflammation‐related biomarkers such as IL‐6, C‐reactive protein, serum ferritin and coagulation index, D‐dimer, were significantly higher (P < .01) in diabetic patients compared with those without, suggesting that patients with diabetes are more susceptible to an inflammatory storm eventually leading to rapid deterioration of COVID‐19.

It can therefore be concluded that SARS‐CoV‐2 pneumonia patients with diabetes are more severe than those without diabetes evaluating from organ damage, inflammatory factors or hypercoagulability, and are more likely to progress into a worse prognosis. Therefore, diabetes might could be considered as a risk factor for the outcome of SARS‐CoV‐2 pneumonia, and more intensive attention should be paid to patients with diabetes, in case of rapid deterioration.

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/dmrr.3319