Diagnosing Myasthenia Gravis with an Ice Pack: NEJM case rep
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A 68-year-old man presented with unilateral ptosis and no other symptoms. The neurologic examination revealed ptosis of the left eye after a sustained upward gaze (Panel A). The movements of the extraocular muscles were normal.

Myasthenia gravis was suspected, and the ice-pack test was performed with the placement of an instant cold pack over the left eye (Panel B). After 2 minutes, the ptosis was substantially diminished (>5 mm), indicating a positive test (Panel C).

The diagnosis was further supported by the presence of serum anti–acetylcholine receptor antibodies and by electrodiagnostic testing, which showed a decremental response to repetitive nerve stimulation.

The ice-pack test can be a useful bedside test to distinguish myasthenia gravis from other causes of ptosis or ophthalmoparesis. The inhibition of acetylcholinesterase activity at a reduced muscle temperature is thought to underlie the observed clinical improvement.

The patient was treated symptomatically with pyridostigmine, and the ptosis was diminished.

Source: https://www.nejm.org/doi/full/10.1056/NEJMicm1509523
Dr. S●●●●●●a R●y and 44 others like this14 shares
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Dr. P●●●●●●●a B●●●●●●●●●●a
Dr. P●●●●●●●a B●●●●●●●●●●a Other
Good case. Thank you
Feb 18, 2020Like
Dr. V●●●●●a r●●●●a K●●●●●●a
Dr. V●●●●●a r●●●●a K●●●●●●a General Surgery
Very good
Feb 18, 2020Like
Dr. K●●●●●e S●●●●●m
Dr. K●●●●●e S●●●●●m General Surgery
When I was studying ug at Guntur medical College our neuro professor Dr.Taraknadh used tell many bedside tests like this.
Feb 24, 2020Like