A 38-year-old woman presented with a 2-year history of asymptomatic, widespread rash. There was no involvement of the nails or mucosal tissue. Numerous investigations, including autoimmune screening, cervical and thoracoabdominal computed tomography, venous Doppler ultrasonography, and angiography of the legs, were normal.
Examination of a biopsy specimen obtained from the abdominal wall revealed dilated vascular spaces in the upper dermis, with perivascular hyalinization (highlighted with period acid–Schiff and collagen IV staining, Panel C), normal numbers of mast cells, and no indication of amyloid deposition.
Which of the following conditions is commonly associated with this finding?
A. Chronic liver disease
B. Cutaneous collagenous vasculopathy
C. Hemophilia A
D. CREST syndrome
Answer to be disclosed shortly!
*The present case appears in NEJM