Diet patterns linked with gut pro-inflammatory, anti-inflamm
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Researchers found that specific foods and nutrients correlated with species known to have mucosal protection and anti-inflammatory effects, according to data published in Gut.

The microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the gut. As microbes thrive on dietary substrates, the question arises whether we can nourish an anti-inflammatory gut ecosystem. Researchers aimed to unravel interactions between diet, gut microbiota and their functional ability to induce intestinal inflammation.

They investigated the relation between 173 dietary factors and the microbiome of 1425 individuals spanning four cohorts: Crohn’s disease, ulcerative colitis, irritable bowel syndrome and the general population. Shotgun metagenomic sequencing was performed to profile gut microbial composition and function. Dietary intake was assessed through food frequency questionnaires. They performed unsupervised clustering to identify dietary patterns and microbial clusters. Associations between diet and microbial features were explored per cohort, followed by a meta-analysis and heterogeneity estimation.

Results:
-- They identified 38 associations between dietary patterns and microbial clusters.

-- Moreover, 61 individual foods and nutrients were associated with 61 species and 249 metabolic pathways in the meta-analysis across healthy individuals and patients with IBS, Crohn’s disease and UC.

-- Processed foods and animal-derived foods were consistently associated with higher abundances of Firmicutes, Ruminococcus species of the Blautia genus and endotoxin synthesis pathways.

-- The opposite was found for plant foods and fish, which were positively associated with short-chain fatty acid-producing commensals and pathways of nutrient metabolism.

Conclusively, they identified dietary patterns that consistently correlate with groups of bacteria with shared functional roles in both, health and disease. Moreover, specific foods and nutrients were associated with species known to infer mucosal protection and anti-inflammatory effects. They propose microbial mechanisms through which the diet affects inflammatory responses in the gut as a rationale for future intervention studies.

Source: https://gut.bmj.com/content/early/2021/03/08/gutjnl-2020-322670
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Dr. S●●●●p N●●h
Dr. S●●●●p N●●h Internal Medicine
There should have been little more elaboration regarding specific food items or dietary patterns associated with anti-inflammatory process/microbiome
Apr 7, 2021Like