Dietary Antioxidant Supplementation in Patients with Glaucom
Glaucoma may be caused by oxidative stress, and several prior studies have suggested that antioxidants could be a promising treatment. The benefits of a new supplement including three food-derived antioxidants (hesperidin, crocetin, and Tamarindus indica) on oxidative stress markers in glaucoma patients were studied.

30 glaucoma sufferers were given four pills twice a day with lots of water for eight weeks. The drug was stopped, and the subjects were followed for another eight weeks. The biological antioxidant potential was determined using a free radical analyser (BAP). The oxidative DNA damage marker 8-hydroxy-2-deoxyguanosine (8-OHdG) was also measured in the urine. Clinical laboratory data was measured in venous blood samples. Aside from that, clinical parameters were logged. In the comparisons, a one-way analysis of variance (ANOVA) was used, followed by Dunnett's test.

--The 8-OHdG level was not reduced. We also divided the patients into groups with high or low oxidative stress.

--In patients with relatively high oxidative stress, the 8-OHdG level was significantly reduced at weeks 4, 8, 12, and 16, and BAP was significantly elevated at weeks 8 and 12.

--In patients with relatively low oxidative stress, the 8-OHdG level was not significantly reduced during supplement intake but was significantly elevated at weeks 12 and 16 while BAP was not significantly elevated.

Finally, in patients with a high level of oxidative stress, an 8-week oral course of antioxidant therapy proved helpful. Dietary supplementation may offer promise in the treatment of disorders caused by oxidative stress in the body.