Difference in outcome of Venovenous versus venoarterial extr
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Researchers hypothesized that among infants with hypoxic-ischemic encephalopathy (HIE), venoarterial (VA), compared to venovenous (VV), extracorporeal membrane oxygenation (ECMO) is associated with an increased risk of mortality or intracranial hemorrhage (ICH).

Retrospective cohort analysis of infants with moderate or severe HIE, gestational age more than 36 weeks, and ECMO initiation less than 7 days of age. The primary outcome was mortality or ICH.

Results:
--Severe HIE was more common in the VA ECMO group (n=57), compared to the VV ECMO group (n=53).

--VA ECMO was associated with a significantly higher risk of death or ICH [57.9% vs. 34.0%, aOR 2.39] and mortality [31.6% vs. 11.3%, aOR 3.06], after adjusting for HIE severity.

In conclusion, Venoarterial extracorporeal membrane oxygenation was linked to a higher risk of mortality or intracranial hemorrhage in hypoxic-ischemic encephalopathy. In this population, VV ECMO can be advantageous.

Source: https://www.nature.com/articles/s41372-021-01089-4
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