Different factors that determines the Morphology of Peripapi
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The frequency of peripapillary retinoschisis (PRS) in eyes with glaucoma and suspected glaucoma was determined using cross-sectional exams, and the pathogenesis of PRS was investigated using spectral-domain optical coherence tomography (SD-OCT).

In 1516 cases involving glaucoma and suspected glaucoma, the disc and macular volume scans were retrospectively reviewed & obtained by SD-OCT and PRS was categorized into two groups based on whether the retinoschisis was closer to the optic nerve over the Bruch’s membrane opening (BMO) (ahead group) or did not go past the BMO (behind group) and then compared the characteristics between both groups.

--The total frequency of PRS was 1.49% in primary open-angle glaucoma (POAG) eyes and 0.59% in glaucoma suspects.

--In the behind group, PRS was mostly detected in the inner layers of the retina (retinal nerve fiber layer: 30.9%, ganglion cell layer: 21.8%, inner plexiform layer: 7.3%). However, in the ahead group, PRS was detected in the outer layers (inner nuclear layer: 10%, outer plexiform layer: 20%, outer nuclear layer: 50%).

--In addition, the eyes in the ahead group had significantly greater axial lengths and significantly smaller spherical equivalent values.

--These two differences suggest that the pulling force of the vitreous traction may play an important role in PRS only in the behind group and that the scleral stretching force may play a role in the development of PRS in the ahead group.

In conclusion, PRS is more common in patients with POAG than in patients with suspected glaucoma. The posterior vitreous detachment and axial length elongation affects both types of PRS. In order to determine the progression of PRS in glaucoma suspects, careful follow-up is needed. By classifying the morphological state of the PRS and BMO, the pathogenesis of PRS has been partially elucidated.

Source: https://www.dovepress.com/factors-determining-the-morphology-of-peripapillary-retinoschisis-peer-reviewed-article-OPTH