Differential Clinical features of Proliferative Diabetic Ret
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A Study was conducted to explore the pathological features and clinical significance of three types of neovascularization elsewhere (NVE) in proliferative diabetic retinopathy.

Neovascularization elsewhere was classified based on the origins and morphologic features using fluorescein angiography and angiographic and structural optical coherence tomography. The topographical distribution, vitreoretinal interface, and responsiveness to panretinal photocoagulation were compared among three types of NVE.

Results:
--127 NVEs were classified into three types. Type 1 NVE was concentrated along or adjacent to vascular arcades; Type 2 was distributed more peripherally than were Types 1 and 3 NVE.

--The arch bridge–like vitreoretinal interface accounted for 79% of Type 1 NVE. The flat and flat-forward vitreoretinal interface accounted for 95% and 100% in Type 2 and Type 3 NVE, respectively.

--At 3 months after panretinal photocoagulation, the regression rates for Types 1, 2, and 3 NVE were 82%, 100%, and 80%, respectively.

--Type 2 NVE showed best regression rate after panretinal photocoagulation.

Finally, three forms of NVE are responsible for the unique topographical distributions, vitreoretinal interface characteristics, and varied reactivity to panretinal photocoagulation. This novel notion could have significant clinical consequences when it comes to determining the management and prognosis of proliferative diabetic retinopathy.

Source: https://journals.lww.com/retinajournal/Abstract/2021/06000/NOVEL_THREE_TYPES_OF_NEOVASCULARIZATION_ELSEWHERE.16.aspx
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