Discoloration of the Macular region in patients with Macular
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A Study was conducted to explore whether the existence and pattern of distribution of macular haemorrhage or exudate can be valuable diagnostic markers for macular neovascularization type 3 (MNV3) in patients with neovascular age?related macular degeneration.

A total of 83 eyes from 83 treatment-naive patients with stage 3 MNV3 were included in the study. Fluorescein angiography (FA) and optical coherence tomography (OCT) were used to make the diagnosis (OCT). Color fundus photography was used to assess subretinal and intraretinal haemorrhage, as well as thick exudates. The axial position of the haemorrhage was determined using fluorescein angiography (FA) images and OCT scans. As two control classes, 83 patients with MNV1 and 83 patients with MNV2 were included.

--In the MNV3 group, 62 eyes had intraretinal haemorrhage and 52 had dense exudates.

--73 eyes had intraretinal haemorrhage and/or dense exudates. 41 had both pathologies. The intraretinal haemorrhage was flame shaped over the lesion and punctate or semi?punctate further away from it and directed to the fovea. No subretinal haemorrhage was noticed.

--In the MNV1 and MNV2 groups, 11 and 24 eyes had subretinal haemorrhage or dense exudates, respectively.

--No intraretinal haemorrhage was seen in the two control groups. The prevalence of exudates and haemorrhage (irrespective of its location) was greater in MNV3 than in MNV1 or 2.

Finally, intraretinal haemorrhage's presence and pattern of distribution are pathognomonic of MNV3. It enables the diagnosis of MNV3 using fundoscopy or a color fundus picture (alone or in combination with dense exudates) and without the need for additional diagnostic costs.

Source: https://onlinelibrary.wiley.com/doi/10.1111/aos.14866?af=R