Distinct Parkinson's disease symptoms tied to different brai
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Parkinson's disease's progression has been largely tied to the loss of motor functions but non-motor symptoms, including the loss of cognitive abilities, often emerge early in the disease. A new study found that specific, identifiable neural pathways are charged with particular functions during stages of the disease. The findings can help form the basis for improving therapeutic strategies for precise symptoms of Parkinson's at various levels of disease progression.

The researchers used a mix of approaches to shed more light on the anatomical and functional importance of a center of brain circuitry known as the basal ganglia, located deep in the cranium. Specifically, the researchers, working in mice, investigated circuit pathways tied to specific neurons in the external globus pallidus, or GPe, and their role in different Parkinson's disease-related behaviors. The GPe is known for its strong output and influence on several downstream brain regions.

The investigations included a multi-pronged approach using electrophysiology, viral tracing, and behavioral experiments. The researchers identified two populations of GPe neurons and their distinctive pathways tied to different behavioral symptoms.

The investigator said- the most surprising finding from the research was the fact that dopaminergic neurons, those that are gradually lost during Parkinson's disease progression, could be linked so specifically to changes in different brain areas.

With the new framework in hand, researchers are now looking deeper at the circuit pathways and how they are tied to different disease symptom stages, in particular with an emphasis on delaying the progression of the disease.

"Our findings provide a novel framework for understanding the circuit basis of varying behavioral symptoms of the Parkinsonian state, which could provide better strategies for the treatment of PD," the researchers write in the paper.

Nature Neuroscience volume
Source: https://doi.org/10.1038/s41593-021-00810-y
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