Diverticular disease is associated with an increased inciden
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The diverticular disease represents a gastrointestinal disorder of high prevalence in developed countries that often leads to psychological distress. This study shows a positive link between depression and anxiety disorders and diverticular disease.

Researchers aimed at evaluating a potential association between diverticular disease and depression or anxiety disorders in outpatients in Germany.

Using the Disease Analyzer database featuring data of over 8 million patients treated in German general practices, investigators identified 61.556 patients with diverticular disease who were 1:1 matched by age, sex, index year, and the Charlson Comorbidity Index to 61.556 patients without the diverticular disease. The association between diverticular disease and depression or anxiety disorders was evaluated in Cox regression models.

--Within 5 years after the initial diagnosis of diverticular disease, 14% of patients with and 10.6% of individuals without diverticular disease were diagnosed with depression.

--Similarly, the incidence of anxiety disorder was significantly higher in patients with diverticular disease.

--Finally, the prescription rate for antidepressant drugs was significantly higher in diverticular disease patients compared to individuals without the diverticular disease. These associations were confirmed for different age groups and both sexes.

Conclusively, the data provide evidence that diverticular disease is associated with an increased incidence of depression and anxiety disorders. Despite the fact that confounding factors such as deprivation and patient personality have to be taken into account, researchers suggest that patients with diverticular disease are regularly screened for symptoms of depression and anxiety disorders.

International Journal of Colorectal Disease
Source: https://doi.org/10.1007/s00384-021-03937-3
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