Dopamine modulation could help to treat stress-induced anhed
The term anhedonia is used to describe the inability to feel pleasure and a disinterest in activities that previously brought positive feelings. This lack of interest and pleasure is a very common symptom of depression, as well as other widespread mental health disorders.

Researchers recently carried out a study on rats, exploring the possibility that drugs targeting dopamine receptors could be better suited for the treatment of anhedonia than those targeting serotonin receptors. Researchers exposed 48 male rats to stressful stimuli for a period of three weeks. Subsequently, they treated half of them using systemic, low-dose injections of the drug Amisulpride, which is known to increase dopamine transmission. The other half was treated using micro-infusions of Quinpirole, a chemical that acts as a selective D2-like receptor agonist, into either the nucleus accumbens or the medial prefrontal cortex, two brain regions known to be associated with motivation and goal-directed behavior. The study suggests the modulation of dopamine could help to reverse stress-induced anhedonia and reward dysfunctions.

Source: https://link.springer.com/article/10.3758/s13415-022-01001-3
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