Drinking coffee may help preserve kidney function in adults
A multicenter prospective study of 3,805 adults aged 20 years or older with type 2 diabetes attending hospitals or clinics certified by the Japan Diabetes Society in Fukuoka, Japan, from April 2008 to October 2010. Coffee consumption was determined through a dietary survey. Participants were divided into four groups: no coffee consumption, less than one cup per day, one cup per day and two or more cups per day. For each participant, eGFR was calculated based on serum creatinine concentration. The study’s primary endpoint was a decline of eGFR to less than 60 mL/min/1.73 m2 based on two consecutive measurements during the follow-up period.

Of the study cohort, 840 had eGFR decrease to less than 60 mL/min/1.73 m2. The risk for eGFR decline was lower for adults drinking less than one cup of coffee per day (HR = 0.77; 95% CI, 0.63-0.93), one cup per day (HR = 0.77; 95% CI, 0.62-0.95) and two cups per day (HR = 0.75; 95% CI, 0.62-0.91) compared with non-coffee drinkers.

Adults who did not drink coffee had eGFR decrease by 2.16 mL/min/1.73 m2 annually, significantly greater than the 1.89 mL/min/1.73 m2 annual eGFR decline in those drinking less than one cup of coffee per day, 1.8 mL/min/1.73 m2 eGFR decline for adults drinking one cup per day and 1.78 mL/min/1.73 m2 decline in those drinking two or more cups per day (P for trend = .03). Compared with non-coffee drinkers, those who drank one cup of coffee daily (adjusted OR = 0.67; 95% CI, 0.47-0.95) or two cups or more per day (aOR = 0.69; 95% CI, 0.5-0.94) were less likely to have a rapid eGFR decline (P for trend = .03). The risk for eGFR decline was lower for participants who drank any amount of coffee compared with those who did not drink coffee (aHR = 0.76; 95% CI, 0.65-0.9).

Coffee consumption was significantly associated with a lower risk of incident kidney disease in patients with type 2 diabetes.
The study suggested that coffee may have some nephroprotective effect.

Source: https://www.healio.com/news/endocrinology/20220429/drinking-coffee-may-help-preserve-kidney-function-in-adults-with-type-2-diabetes
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