Drug Combo Administered During In-Hospital Cardiac Arrest To
A study revealed that administration of vasopressin and methylprednisolone to patients with in hospital cardiac arrest significantly improved return of spontaneous circulation, compared with placebo. Study was carried out on 501 patients at 10 hospitals throughout Denmark to receive either a combination of vasopressin 20 IU and methylprednisolone 40 mg (n = 237 patients) or placebo (n = 264 patients) after the first dose of epinephrine. Additional doses of vasopressin or corresponding placebo were administered after each additional dose of epinephrine, for a maximum of four doses. One hundred patients in the vasopressin and methylprednisolone group (42%) and 86 patients in the placebo group (33%) achieved return of spontaneous circulation. At 30 days, 23 patients in the intervention group (9.7%) and 31 patients in the placebo group were alive. It was concluded that among patients with in-hospital cardiac arrest, administration of vasopressin and methylprednisolone, compared with placebo, significantly increased the likelihood of return of spontaneous circulation.

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