Dynamic optical coherence tomography shows alterations of bl
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Dynamic optical coherence tomography (D-OCT) allows in vivo visualization of blood vessels in the skin and in malignant tumors. Vessel patterns in malignant melanoma may be associated with tumor stage. The aim of this study was to describe blood vessel patterns in melanomas and to correlate them with stage.

159 malignant melanomas were assessed in a multicenter study. Every tumor was imaged using D-OCT prior to surgery and histologic evaluation. The tumor data like thickness and ulceration as well as the staging at primary diagnosis and a follow-up of at least 40 months resulted in a stage classification. The vessel patterns were assessed according to pre-defined categories, compared to healthy adjacent skin and correlated to stage.

Results:
-Melanomas contained more blood vessels in different patterns compared to healthy adjacent skin.
-In particular, irregular vascular shapes like blobs, coils, curves and serpiginous vessels were more common in melanomas.
-In addition, these patterns were significantly more often found in high-risk and metastatic melanomas than in low-risk lesions.

Conclusively, in melanomas, the density of the blood vessels is increased, and irregular vascular patterns are more frequent. At higher stages, especially in metastatic melanomas, these atypical vessels are significantly more common.

Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.17080
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