E. coli is the most Common & Causative bacteria among pediat
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Urinary tract infections (UTIs) are the most common bacterial infections in children. This study aimed to review characteristics of causative bacteria and effectiveness of antimicrobial therapy in children with febrile UTIs. Clinical records of 108 patients with febrile UTIs were retrospectively reviewed. The characteristics of the causative bacteria, antibacterial therapy, and therapeutic effect were verified.

Results:
--Patients aged between 0–183 months (median age: 3 months) and 73 (67.6%) were males.

--63 episodes were diagnosed with complicated UTIs. 47 episodes were observed in patients aged less than 3 months; 15 of them had complicated UTIs.

--Escherichia coli (E. coli) was the most common pathogen, followed by Enterococcus faecalis (E. faecalis). Blood cultures were positive in three episodes.

--Among the 130 episodes, 62 were treated with a combination of ampicillin (ABPC) and third-generation cephalosporins, followed by third-generation cephalosporins (31 episodes) and sulbactam sodium/ampicillin sodium (SBT/ABPC; 15 episodes).

--In case of uncomplicated/complicated UTIs and patients aged less than 3 months and more than 3 months, the most common pathogen was E. coli, followed by E. faecalis in each group.

--There was no difference in therapeutic effects between “combination ABPC and third-generation cephalosporins” and “third-generation cephalosporin monotherapy” administered for the treatment of UTIs caused by E. coli.

In particular, E. coli is the most common pathogen among pediatric UTIs. For the antibacterial therapy, third-generation cephalosporin monotherapy is effective and may not require combination therapy with ABPC.

Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/ped.14639?af=R
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