Early Induction Of Functional SARS-CoV-2-specific T Cells Li
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Humoral and cellular adaptive immunity are two immune mechanisms that act against pathogens. Their roles in viral control or disease pathogenesis is not fully understood. Studying how these immune mechanisms mediate SARS-CoV-2 infections could be beneficial in controlling the progression of the disease.

To fill this knowledge gap, the team of researchers investigated the changes in virological and immunological parameters in 12 patients with symptomatic acute SARS-CoV-2 infection from the onset of the disease to recovery or death. "Our data support the idea that SARS-CoV-2 specific T cells play an important role in the rapid control of viral infection and eventual clearance of the disease," added Dr Martin Linster, Senior Research Fellow with Duke-NUS' EID programme.

The team analyzed SARS-CoV-2 specific T cell response in COVID-19 patients at convalescence. In this study, they have expanded the analysis to the full timeline of the infection. "It is time that T cell monitoring should be considered in providing a comprehensive understanding"

"This important study furthers our understanding of the immune response against SARS-CoV-2. It has far-reaching implications including on COVID-19 vaccine design and the subsequent monitoring of vaccine response," said Professor Patrick Casey, Senior Vice-Dean for Research at Duke-NUS.

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