Early Nitazoxanide Therapy Significantly Reduces Viral Load
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Early nitazoxanide therapy is safe and helps in a significant reduction of viral load in patients with mild Covid-19, suggests a recent study in medRxiv. However, it did not help in symptom resolution compared to placebo after 5 days of therapy.

The multicenter, randomized, double-blind, placebo-controlled trial enrolled 1,575 adult patients who presented up to 3 days after onset of Covid-19 symptoms (dry cough, fever, and/or fatigue) Patients were randomized in the ratio 1:1 to receive either nitazoxanide (500 mg) or placebo, TID, for 5 days.

The primary outcome was complete resolution of symptoms. Secondary outcomes were viral load, general laboratory tests, serum biomarkers of inflammation, and hospitalization rate.

Key findings of the study include:

1. Median time from symptom onset to the first dose of study drug was 5 (4-5) days.

2. At the 5-day study visit, symptom resolution did not differ between the nitazoxanide and placebo arms.

3. At the 1-week follow-up, 78% in the nitazoxanide arm and 57% in the placebo arm reported complete resolution of symptoms.

4. Swabs collected were negative for SARS-CoV-2 in 29.9% of patients in the nitazoxanide arm versus 18.2% in the placebo arm.

5. Viral load was also reduced after nitazoxanide compared to placebo.

6. No serious adverse events were observed.

Source: https://www.medrxiv.org/content/10.1101/2020.10.21.20217208v1.full
S●●●y S●●●●t and 51 others like this32 shares
Dr. S●●●●●●●●●●n K●●●●●●i
Dr. S●●●●●●●●●●n K●●●●●●i Family Medicine
Good study in Covid-19 therapy
Oct 27, 2020Like
Dr. R●●●●●●●●r G●●●●i
Dr. R●●●●●●●●r G●●●●i pediatrics
Good information
Oct 28, 2020Like
Dr. M●●●●●l Q●●●r
Dr. M●●●●●l Q●●●r Obstetrics and Gynaecology
Nice information
Nov 1, 2020Like