Early Vitrectomy is associated with better visual outcomes i
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A Study was conducted to examine the role of early vitrectomy in the management of endophthalmitis from all causes that inferred better clinical outcomes.

Retrospective study of 290 consecutive subjects diagnosed with endophthalmitis were included. Main outcome measure was visual acuity at 9-month follow-up and proportion of subjects with severe vision loss (less than 20/200).

Results:
--Median age at presentation was 70.4 years and 151 subjects were women. Cataract surgery was the most common cause of endophthalmitis in 92 subjects followed by intravitreal injection in 57, endogenous endophthalmitis in 48 subjects, non-surgical trauma in 42 subjects, glaucoma surgery in 24 subjects, vitrectomy in 22 subjects and corneal in 5 subjects.

--Culture was positive in 136 with gram-positive organisms most common.

--Early vitrectomy was performed in 82 subjects. Median visual acuity at 9 months was 20/100 (IQR 20/30 to light perception), and severe vision loss occurred in 100.

--Retinal detachment occurred in 35 eyes and 26 eyes were enucleated.

--On multivariate analysis, younger age, poor presenting visual acuity and culture-positive endophthalmitis were associated with worse outcomes, and early vitrectomy was associated with better outcomes.

Finally, early vitrectomy (within 24 hours) is linked to better visual outcomes at 9 months, while younger age, low presenting visual acuity, and culture-positive endophthalmitis are linked to poorer visual acuity outcomes at 9 months.

Source: https://bjo.bmj.com/content/early/2021/03/11/bjophthalmol-2020-316846?rss=1
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