Early glaucoma RNFL thinning rates in different Glaucomatous
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A Study was conducted to compare spectral-domain optical coherence tomography (SDOCT) measured circumpapillary retinal nerve fiber layer (cpRNFL) among four glaucomatous optic disc phenotypes in early glaucoma.

218 early glaucoma eyes with at least 3 years of follow-up and at least 4 SDOCT scans were included in this report. On the basis of appearance, the optic discs were divided into four groups: 76 generalized cup enlargement (GE), 53 focal ischemic (FI), 22 myopic glaucomatous (MY), and 67 senile sclerotic (SS). The rates of global and regional cpRNFL thinning among optic disc phenotypes were compared using a linear mixed-effect model.

Results:
--After adjusting for confounders, the SS group (mean (95% CI): -1.01 had the fastest mean rate of global cpRNFL thinning followed by FI (-0.77), MY (0.59) and GE (-0.58).

--The inferior temporal sector had the fastest rate of cpRNFL thinning among the regional measurements except for the MY group (-0.68).

--In the multivariable analysis, GE and MY phenotypes were associated with significantly slower global rates of cpRNFL thinning when compared to the SS phenotype.

Finally, the four glaucomatous optic disc phenotypes had different rates of cpRNFL thinning. Early glaucoma patients with the SS phenotype have the highest cpRNFL thinning. More frequent monitoring and the need to advance therapy if cpRNFL thinning is detected can benefit these patients.

Source: https://www.ajo.com/article/S0002-9394(21)00201-4/fulltext?rss=yes
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