Early-onset climacterium is not associated with impaired vit
The objective was to investigate vitamin D status in women with the onset of the climacteric phase by age 46 as both early menopause and inadequate vitamin D status may increase the risk of adverse health outcomes.

A cross-sectional study included 2,544, 46-year-old women from a birth cohort. Women were divided into the following two groups according to their menstrual history and follicle-stimulating hormone (FSH) concentration: 1) climacteric (FSH ≥25 IU/L and amenorrhea ≥4 mo, n = 351) and 2) preclimacteric women (FSH <25 IU/L and having regular/irregular menstrual cycles, n = 2,193). Serum 25-hydroxyvitamin D (25(OH)D) concentrations were compared between the groups.

- Mean serum 25(OH)D concentrations were higher in climacteric compared with preclimacteric women. However, in the linear regression model, climacteric status was not associated with 25(OH)D status.

- A total of 76 of the climacteric women were using systemic estrogen hormone therapy (HT). In a subanalysis, including only climacteric women, the use of HT was associated with a higher 25(OH)D status.

The onset of the climacteric phase by age 46 was not associated with inadequate 25(OH)D concentrations, whereas HT use was associated with higher 25(OH)D status in women with early-onset climacterium.

Source: https://journals.lww.com/menopausejournal/Abstract/2021/08000/Early_onset_climacterium_is_not_associated_with.10.aspx