Early puberty and risk for type 2 diabetes in men- A study f
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The study included 30,697 men who had data for BMI at age 8 and 20 years and age at Peak Height Velocity (PHV), an objective assessment of pubertal timing, available from the BMI Epidemiology Study Gothenburg, Sweden. Information on type 2 diabetes (n = 1851) was retrieved from the Swedish National Patient Register. HRs and 95% CIs were estimated by Cox regression analysis. We observed violations of the assumption of proportional hazards for the association between age at PHV and the risk of type 2 diabetes and therefore split the follow-up period at the median age of type 2 diabetes diagnosis (57.2 years of age) to define early (≤57.2 years) and late (>57.2 years) type 2 diabetes diagnosis.

Results: Age at PHV was inversely associated with both early and late type 2 diabetes. After adjustment for childhood BMI, the associations between age at PHV and both early and late type 2 diabetes were similar. Moreover, early age at PHV predicted insulin treatment of type 2 diabetes. Assuming a higher risk among those with an age at PHV below the median, the population attributable factor indicates that 15% fewer of the diagnosed individuals would have developed type 2 diabetes had they not reached puberty early.

Conclusively, The results demonstrate that early pubertal timing is associated with increased risk of type 2 diabetes in Swedish men, independent of prepubertal BMI.

Source: https://link.springer.com/article/10.1007/s00125-020-05121-8
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