Early success transplanting kidneys from donors with new SAR
Transplantation of solid organs from donors with active SARS-CoV-2 infection has been advised against due to the possibility of disease transmission to the recipient.

In this setting, researchers put forth a strategy to transplant otherwise healthy extra-pulmonary organs from SARS-CoV-2 infected donors. They transplanted ten kidneys from five deceased donors with new detection of SARS-CoV-2 RNA during donor evaluation in early 2021.

KDPI ranged from 3 to 56%. All organs had been turned down by multiple other centers. Without clear signs or symptoms, the veracity of the timing of SARS-CoV-2 infection could not be confirmed.

With eight to sixteen weeks of follow-up, outcomes for all ten patients and allografts have been excellent. All have been free of signs or symptoms of donor-derived SARS-CoV-2 infection.

The findings raise important questions about the nature of SARS-CoV-2 RNA detection in potential organ donors and suggest an underutilization of exceptionally good extra-pulmonary organs with a low risk for disease transmission.

American Journal of Transplantation
Source: https://doi.org/10.1111/ajt.16765