Earwax test to measure glucose levels could allow earlier id
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The onset of type 2 diabetes could be detected earlier in life thanks to a test which measures glucose levels in one's earwax, a study has claimed. The full findings of the study were published in the journal Diagnostics. UK-led experts said that the cheap measurement is almost '60 per cent more reliable' at measuring glucose levels averaged over a month that the current standard test.

In addition, the team said that the test — which can be conducted at home without clinical supervision — could also be applied to measure COVID-19 antibodies.

The tip of the prove, the team said, is treated with a solution which tests have indicated to be the most effective at collecting earwax samples for analysis.

In their study, the researchers recruited 37 participants who did not have diabetes to put the probe through its places. Participants provided standard serum, glycated hemoglobin (HbA1c) and earwax samples at two time-points, one month apart.

The specimens measured baseline fasting glucose, a follow-up postprandial glucose level and a between sample chronic glucose, calculated using the average level on the two occasions. The baseline earwax sample was obtained using a clinical method and the follow-up using a novel self-sampling earwax device. The earwax analytic time was significantly faster using the novel device, in comparison to the clinical use of the syringe.

Earwax accurately reflected glucose at both assessments with stronger correlations than HbA1c. Follow-up postprandial concentrations were more significant than their respective fasting baseline concentrations, reflecting differences in fasting and postprandial glycemia and more efficient standardization at follow up.

Earwax demonstrated to be more predictable than HbA1c in reflecting systemic fasting, postprandial and long-term glucose levels, and to be less influenced by confounders. Earwax glucose measurements were approximately 60% more predictable than HbA1c in reflecting glycemia over a month. The self-sampling device provided a sample that might accurately reflect chronic glycemia.

Previous research by the team demonstrated that the device can also measure the stress hormone cortisol — a capacity which may one day be used to help monitor depression and stress-related conditions.

'This new device may allow mass screening and earlier identification of type 2 diabetes.'

Source: https://www.mdpi.com/2075-4418/10/12/1069/htm
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