Ectopic axillary breast cancer in a male patient
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Ectopic breast tissue can persist in the axilla due to lack of involution of mammary glands along the mammary lines. It is rare in men, and the malignant transformation to breast cancer has occasionally been described. Differential diagnosis of any axillary tumor should include breast cancer arising at ectopic sites.

An 81-year-old male patient presented with an erythematous hard nodule on the right axilla. After the excisional biopsy, histopathological findings showed invasive adenocarcinoma with apocrine characteristics. Histopathological criteria for a breast carcinoma of the NST type with apocrine differentiation were fulfilled. The tumor showed an infiltrative growth, and the carcinoma cells consisted of eosinophilic cytoplasm, high-grade nuclei, and prominent nucleoli. The carcinoma cells expressed breast-specific markers as Ck7, mammaglobin, NY-BR-1, brst2, and GATA3. The carcinoma was triple-negative with Ki67 at 15-20%.

The histological features were consistent with a primary breast carcinoma in the axilla. Although there was no breast-specific anatomical structures around the carcinoma, the whole histological and immunophenotypical context is diagnostic for primary breast carcinoma.

The patient underwent complete resection of the primary tumor, axillary lymph node dissection, followed by adjuvant regional radiotherapy.

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.3336?af=R
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