Effect of Achieving Target Intraocular Pressure on Visual Fi
A Study was conducted to estimate the effect of achieving target intraocular pressure (IOP) values on visual field (VF) worsening in a treated clinical population.

2,852 eyes of 1,688 patients with glaucoma-related diagnosis were included. All included eyes had at least 5 reliable VF tests and five IOP measures on separate visits along with at least one target IOP defined by a clinician on the first or second visit.

The primary dependent variable was the slope of the mean deviation (MD) over time (dB/yr). The primary independent variable was mean target difference (measured IOP – target IOP). Researchers created simple linear regression models and mixed effects linear models to study the relationship between MD slope and mean target difference for individual eyes.

--Across all eyes, a simple linear regression model demonstrated that a 1 mmHg increase in target difference had a -0.018 dB/yr effect on MD slope.

--The mixed effects model shows that eyes with moderate disease who fail to achieve their target IOP experience the largest effects, with a 1 mmHg increase in target difference resulting in a 0.119 dB/yr worse MD slope.

--The effects of missing target IOP on VF worsening were much more pronounced than the effect of absolute level of IOP on VF worsening, where a 1 mmHg increase in IOP had a -0.004 dB/yr effect on the MD slope.

Conclusively, In treated patients, failing to achieve target IOP was associated with more rapid VF worsening. Eyes with moderate glaucoma experienced the greatest VF worsening from failing to achieve target IOP.

Source: https://www.aaojournal.org/article/S0161-6420(21)00645-X/fulltext?rss=yes