Effect of Antipsychotic use with longer In-hospital Lengths
The purpose of this study was to investigate whether patients taking antipsychotic medications at the time of their primary TKA have higher rates of in-hospital lengths of stay (LOS), VTEs, and costs of care. Studies have shown that antipsychotic medication use may lead to venous thromboembolisms (VTEs); however, this association has not been demonstrated in patients undergoing primary total knee arthroplasty (TKA).

Patients taking antipsychotic medications were identified and matched to a cohort in a 1:5 ratio by age, sex, and medical comorbidities. Patients who had a history of VTEs or hypercoagulable states before their TKA were excluded. The query resulted in 439,579 patients within the study (n = 73,285) and matching cohorts (n = 366,294). Outcomes analyzed included rates of in-hospital LOS, VTEs, and costs of care.

Results:
--Researchers found statistically significant longer in-hospital LOS for patients taking antipsychotic medications (3.27 versus 3.02 days).

--Study patients were also found to have a higher incidence and odds ratio of VTEs (2.37 versus 1.04%).

--90-day costs of care were also significantly higher in the study cohort.

Finally, patients receiving antipsychotic therapy were found to have increased hospital LOS, VTEs and cost of treatment after adjustment to the confounders. The data might be used by orthopedic surgeons to counsel patients about the possible consequences after the treatment.

Source: https://journals.lww.com/jaaos/Abstract/2021/07010/Antipsychotic_Use_Is_Associated_With_Longer.12.aspx
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