Effect of Cataract surgery on Wet age?related Macular degene
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Wet age-related macular degeneration (AMD) and age-related cataract are often seen together as causes of vision loss. However, the timing of cataract surgery in patients with wet AMD is debatable.

Cataract surgery was performed on 111 eyes of 111 patients with wet AMD. Best corrected visual acuity (BCVA) and central subfield macular thickness (CSMT) were measured at the time of wet AMD diagnosis, the last recording prior to cataract surgery, and the first recording and one year after cataract surgery. Antivascular endothelial growth factor (antiVEGF) injections, systemic and topical medication, and postoperative antiVEGF burden were all reported.

Results:
--Mean age was 78.9 ± 5.6 years at the time of surgery. Central subfield macular thickness (CSMT) significantly decreased (280.1 ± 75.0 microm preoperatively to 268.6 ± 67.6 microm at the first postoperative recording, and to 265.9 ± 67.9 microm at 1 year), visual acuity improved (0.70 ± 0.46 logMAR units preoperatively to 0.39 ± 0.40 at the first postoperative recording, and to 0.33 ± 0.34 at 1 year for both) and anti?VEGF treatment intervals lengthened despite the surgery.

--A CSMT increase of over 30% from the preoperative values was seen in only one case (1 out of 111 eyes, 0.9%).

--Macular status at surgery, wet AMD subtype, comorbidity of type II diabetes, systemic drugs and topical anti?inflammatory medication were not associated with macular changes nor with treatment intervals after surgery.

--The cumulative number of anti?VEGF injections correlated neither with CSMT change postoperatively (r = ?0.051) nor with CSMT change at 1 year (r = 0.091).

Finally, patients with wet AMD who underwent cataract surgery had satisfactory visual results and monitored disease activity.

Source: https://onlinelibrary.wiley.com/doi/10.1111/aos.14864?af=R
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