Effect of Donor Age and Corneal Endothelial Cell Density on
Researchers aimed to study the causes of non-utilization of donor corneas and assess whether non-utilized tissues differ from utilized tissues with regard to age and endothelial cell density (ECD).

A retrospective, cross-sectional analysis of all donor corneas collected from a network of 4 eye banks was conducted. All donor corneas were assessed for tissue quality by slit lamp evaluation, donor age, and specular microscopy. The causes of non-utilization and effect of donor age and ECD on tissue utilization were studied.

--A total of 10,969 corneas were harvested during the study period; 4618 (42.1%) tissues were discarded.

--The main causes of non-utilization were poor tissue quality accounting for 86.16% (n = 3979) of all discarded corneas.

--The mean donor age was 50.7 ± 2.9 years and 63.3 ± 2.3 years for used and discarded corneas, respectively.

--The mean ECD of donor tissues was significantly higher in the utilization group (2787.3 ± 77.4 cells/mm2) than that in the non-utilization group (2394.4 ± 82.5 cells/mm2).

--Donor age and ECD and their interaction were significant predictors of tissue utilization rate.

Conclusively, the rate of use of donor corneal tissues was substantially linked with donor age, ECD, and their interaction.

Source: https://journals.lww.com/corneajrnl/Abstract/9000/Effect_of_Donor_Age_and_Corneal_Endothelial_Cell.95689.aspx