Effect of LH supplementation in poor responders in assisted
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The study suggests that LH supplementation, though essential in poor ovarian responders (PORs), does not improve clinical pregnancy rates.

The aim was to compare granulosa cell's (GCs) apoptosis rate with (group A) or without (group B) luteinising hormone (LH) supplementation in poor ovarian responders (PORs) during controlled ovarian stimulation (COS).

After oocyte retrieval, the follicular fluid was analysed by cytoflowmetry. Primary outcomes were GCs apoptosis rate in terms of viability, early apoptosis, late apoptosis and necrosis. Secondary outcome was clinical pregnancy rate.

The viability was 96.7 for groups A and B, respectively. Late apoptosis rates were significantly lower in group A than group B. Median early apoptosis rates were 1.4 for group A and B respectively.

No significant difference was observed in the clinical pregnancy rate. Although LH seems necessary in PORs to decrease late granulosa apoptosis rates, this does not improve clinical pregnancy rates.

Journal of Obstetrics and Gynaecology
Source: https://doi.org/10.1080/01443615.2021.1873921
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