Effect of Sevoflurane Anesthesia for dental procedure on Neu
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It was discovered that dental procedures performed under general anesthesia (DGA) improved the oral health-related quality of life of children. The aim of this study was to see whether DGA has an adverse effect on neurocognition in children.

In this prospective, assessor-masked, controlled, equivalence trial, 340 children younger than 7 years who were undergoing caries treatment were recruited without factors affecting neurodevelopment. They received either sevoflurane-based general anesthesia or awake-local anesthesia.

The Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition was used to evaluate the neurocognitive function of children at 6 months after surgery, and the Full-Scale IQ (FSIQ) was selected as the primary outcome. The predefined clinical equivalence margin was 5 (1/3 SD of FSIQ score).

Results:
--The outcome data were obtained from 129 children in the general anesthesia group and 144 in the local anesthesia group.

--The median length of general anesthesia was 130 min (IQR 110–160).

--The mean FSIQ score in the general anesthesia group was 103·12 and the mean of the local anesthesia group was 103·58.

--There was equivalence in means of FSIQ score between the two groups (local minus general anesthesia 0.46).

--There was no significant difference in FSIQ scores between different age groups and different anesthesia durations. Only the mother’s education could affect the primary outcome.

Finally, relative to awake-local anesthesia, extended DGA with a sevoflurane-only anesthetic has no negative effects on neurocognitive activity at 6 months after surgery in preschool children.

Source: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-021-02649-5
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