Effect of electrical activity of the diaphragm waveform patt
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This study aimed to evaluate the association between electrical activity of the diaphragm (Edi) waveform patterns and peripheral oxygen saturation (SpO2) in extremely preterm infants who are ventilated with neurally adjusted ventilatory assist (NAVA).

A retrospective cohort study was conducted at a level III neonatal intensive care unit. Extremely preterm infants ventilated with NAVA were included. Edi waveform data were collected and classified them into four Edi waveform patterns, including the phasic pattern, central apnea pattern, irregular low voltage pattern, and tonic burst pattern.

The Edi waveform pattern were analyzed for the first 15h of collectable data in each patient. To investigate the association between Edi waveform patterns and SpO2, the dataset was analyzed every 5min as one data unit. The proportion of each waveform pattern between the desaturation (Desat [+]) and non-desaturation (Desat [–]) groups were compared.

Results:
--Collected data was analyzed for 105h. The proportion of the phasic pattern in the Desat (+) group was significantly lower than that in the Desat (–) group.

--However, the proportions of the central apnea, irregular low voltage, and tonic burst patterns in the Desat (+) group were significantly higher than those in the Desat (–) group.

In conclusion, these findings suggest that the proportions of Edi waveform patterns have an impact on SpO2 desaturation in extremely preterm infants ventilated with NAVA.

Source: https://onlinelibrary.wiley.com/doi/10.1002/ppul.25396?af=R
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