Effect of high-dose vitamin D supplementation on peripheral
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Although high-dose vitamin D supplementation is common, effects on arterial calcification remain unexplored. Tibial artery calcification was identified and quantified over 3 years in participants randomized to 400, 4000, or 10,000 IU vitamin D3 daily. High-dose vitamin D supplementation did not affect the development or progression of arterial calcification. To determine whether vitamin D supplementation has a dose-dependent effect on the development and progression of arterial calcification a study was conducted.


This was a secondary analysis of the Calgary Vitamin D Study, a 3-year, double-blind, randomized controlled trial. Participants were aged 55–70 years with serum 25-hydroxyvitamin D 30–125 nmol/L. Participants were randomized 1:1:1 to receive vitamin D3 400, 4000, or 10,000 IU/day for 3 years. Tibial artery calcification was identified and quantified (in milligrams of hydroxyapatite, mgHA) using high-resolution peripheral quantitative computed tomography at baseline and 6, 12, 24, and 36 months. Changes in calcification over time and treatment group interaction were evaluated using a constrained linear mixed-effects model.

Of 311 randomized participants, 302 (400: 105, 4000: 96, 10,000: 101) were eligible for analysis of arterial calcification (54% male) age 62 years, mean 25-hydroxyvitamin D 78.9 (19.9) nmol/L). At baseline, 85 (28%) had tibial artery calcification, and mean (95% CI) calcification quantity was 2.8 mgHA. In these 85 participants, calcification quantity increased linearly by 0.020 mgHA/month throughout the study, with no evidence of a treatment-group effect. No participants developed new arterial calcifications during the study.

In this population of community-dwelling adults who were vitamin D replete at baseline, supplementation with vitamin D 400, 4000, or 10,000 IU/day did not have differential effects on the development or progression of arterial calcification over 3 years.

Source: https://link.springer.com/article/10.1007/s00198-020-05500-2
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