Effect of laparoscopic ovarian drilling on serum anti-Muller
PCOS (polycystic ovarian syndrome) is the most common cause of anovulatory infertility, the purpose of the study was to see the effect of laparoscopic ovarian drilling on the ovarian reserve (with AMH as an indicator of ovarian reserve) and its safety as 2nd line of treatment in patients resistant to clomiphene citrate.

This was a prospective interventional study conducted on 40 clomiphene citrate-resistant PCOS women attending the infertility OPD. This study was conducted over a period of 1 year. Laparoscopic ovarian drilling (LOD) was done and these subjects were studied preoperatively and postoperatively on day 7 and day 30 for change in AMH (anti-Mullerian hormone) levels.

There is a significant change in the AMH level post-LOD days 7 and 30 but not so severe that it will lead to premature ovarian failure. The amount of drop-in AMH (day 30) increases to 20 ng/ml beyond which it shows a decrease.

In particular, if LOD is done in a proper manner in women with sufficient ovarian reserve (high AMH), it will not adversely affect ovarian reserve.

International Journal of Reproduction, Contraception, Obstetrics, and Gynecology
Source: https://dx.doi.org/10.18203/2320-1770.ijrcog20213190