Effect of probiotic supplementation on vaginal microbiome du
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The probiotic supplementation may be useful in regulating the interaction network of the vaginal microbiome. Therefore a study was conducted to evaluate the effect of probiotic supplementation on the vaginal microbiome and provide effective evidence for clinical management of pregnant women.

A total of 28 healthy pregnant women at 32 weeks of gestation were enrolled. The women were divided randomly to the probiotic group where they were prescribed with 2 g combined probiotics daily (13 cases) during the third trimester of pregnancy or to the control group (15 cases) on a voluntary basis. Their vaginal samples were taken for analyzing the microbiome with the 16S rDNA amplicon sequencing of the V4 region.

The complexity of the vaginal microbial networks increased from 32 weeks of gestation to antepartum. Lactobacillus was the dominant microbiota. The probiotic supplementation had no obvious influence on the structure of the vaginal microbiome, whereas the relationships of some pivotal vaginal microbiota at the genus level changed in the probiotic group.

The vaginal microbiome varied during the third trimester of pregnancy. The features of the vaginal microbiota after probiotic supplementation had shifted and the interaction network had the tendency to be loose.

Source:https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/jog.14434?af=R
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