Effect of silicone oil on peripapillary capillary density in
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Silicone oil (SO) tamponade, widely used in vitreoretinal surgery, is known to be associated with various complications including cataract, keratopathy, glaucoma, and optic neuropathy. Optic neuropathy following SO tamponade, subclinical or visually significant, is reported to occur at an incidence rate varying from 0 to 28%. The pathogenesis of SO related optic neuropathy remains unclear. Possible mechanisms may include high intraocular pressure (IOP). A study was done to evaluate the effect of silicone oil (SO) on peripapillary blood flow using OCT angiography.

Twenty-two patients were analyzed. The average duration of SO tamponade was 101.3?days. After SO removal, global RPC VD increased by 1.3%, compared with a???0.4% change in contralateral eyes. The increase in RPC VD after SO removal mainly occurred in the superior hemifield, which was 1.6%. The increase in RPC VD in the inferior hemifield was 1.0% after SO removal.

In patients who underwent vitrectomy and SO tamponade for RRD repair, detected a mild increase in peripapillary capillary vessel density after SO removal, mainly in the superior hemifield of the peripapillary area. Findings suggested that SO removal was associated with a recovery of peripapillary microvascular blood flow, possibly due to the release of vascular compression. Results implied that the use of SO should be held with caution due to its potential negative impact on optic nerve microcirculation, even when the duration of SO tamponade does not exceed four months. This study also added new insights to the complex biologic mechanisms of SO related optic neuropathy.

Source:https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01533-7
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